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Antibiotic biosynthesis pathways mechanisms

Keywords Antibiotic biosynthesis pathways Phosphate and nitrogen control Pathway-specific regulators Streptomyces regulatory mechanisms Two component systems... [Pg.115]

Lack of Repression of the Shildmic Acid Pathway.—It is well established that a control mechanism on the shikimic acid pathway is by repression of enzymes early in the pathway by the end products, e.g. by phenylalanine. Cases where this type of control appear to have broken down have now been reported. Lowe and Westlake, in studying the biosynthesis of the phenolic antibiotic chloramphenicol in Streptomyces sp. 3022a, examined several enzymes of the pathway, notably chorismate mutase and anthranilate synthetase, but could find no evidence that end-product control on chloramphenicol synthesis was operating in this organism. Similarly, Chu and Widholm fed phenylalanine and tyrosine to a range of tissue cultures of higher plants, but were not able to observe any evidence of feedback control on chorismate mutase levels. [Pg.217]


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