Antiallergenic effects

Apart from antioxidant activity (see Chapter 9), Maillard products have been found to have antimutagenic, antibiotic, and antiallergenic effects. Chemopreventive effects were mentioned at the beginning of this chapter. 

Ten years later, Taylor et al. [84] published a study on the effects of Upo-some encapsulation on the pharmacokinetics in humans of sodium cromoglycate, a water-soluble antiasthmatic/antiallergenic compound. The dmg was formulated in dipalmitoylphosphatidylcholine/cholesterol (DPPC/CH) (1 1 molar ratio) liposomes and administered as a nebulized aerosol. The researchers demonstrated that, compared with drug administered in solution, the liposomally encapsulated dmg achieved a lower C ax and prolonged plasma half-life, indicating that the liposomes were controlling dmg delivery. 

One year after the introduction of fludrocortisone, the A-corticoids were brought forth into clinical medicine. Investigators at Sobering observed that the 1-dehydro derivatives of cortisone and hydrocortisone—namely, prednisone and prednisolone—are more potent antirheumatic and antiallergenic agents than the parent compounds and produced fewer undesirable side effects. These compounds are known as A -corticoids, because they contain an additional double bond between positions 1 and 2 (Fig. 33.10). 

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