Anti-MUCl antibodies

A. L. Sorensen, C. A. Reis, M. A. Tarp, V. Sankaranarayanan, T. Schwientek, R. Graham, J. Taylor-Papadimitriou, M. A. Hollingsworth, J. Burchell, and H. Clausen, Chemoenzymatically synthesized multimeric Tn/STn MUC1 glyco-peptides elicit cancer-specific anti-MUCl antibody responses and override tolerance, Glycobiology, 16 (2006) 96-107. 

Hamann, P. R. Hinman, L. M. Beyer, C. R Greenberger, L. M. Lin, C. Lindh, D. Menendez, A. T. Wallace, R. Durr, R. E. Upeslacis, J. An anti-MUCl antibody-calicheam-icin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjug. Chem. 2005, 16, 346-353. 

Healthy individuals normally either do not have autoantibodies or have them at a very low titer, and a change or rise can signify the development of cancer or another disease state. A number of cancer antigens have been investigated for their ability to induce detectable autoantibodies, including p53, MUCl, c-myc, and c-erbB-2. For example, accumulation of mutant p53 proteins within tumor cells may lead to the development of autoantibodies. Nine percent to 48% of primary breast cancer patients have detectable anti-p53 antibodies, as do 11% to 64% of lung cancer patients. Anti-p53 antibodies have also been detected in hepatocellular, bladder, colorectal, gastric, and other cancers. ... 

Selected human transmembrane-bound (TM) mucins and secreted mucins are listed, including those that form a mucus gel (Gel). The highly O-glycosylated Ser/Thr/Pro-rich variable number of tandem repeats (VNTR) show a representative amino acid sequence in one of the repeats. The underlined sequence in MUCl is a peptide epitope recognized by anti-MUC1 antibody SM3. Some of the tissues expressing these mucins are listed but most mucins are widely expressed and found in many other tissues and cell types. 

Ismaili, A., Jalali-Javaran, M., Rasaee, M.J., Rahbarizadeh, E, Forouzandeh-Maghadam, M., and Memari, H.R. (2007). Production and characterization of anti-(mucin MUCl). single-divalent antibody in tobacco (Nicotiana tofcflCMm cultivarXanthi). Biotechnol. Appl. Biochem. 47(1) 11-19. 

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