Anthracycline antibiotics antitumor agents

Daunomycin and its analog adriamycin are in clinical use as potent antitumor agents in combination chemotherapy against acute lymphocytic leukemia. It has been suggested that the antitumor properties are associated with intercalation of the anthracycline ring of the antibiotic into the DNA of rapidly proliferating neoplastic cells and subsequent blocking of RNA synthesis (72-75). [5]... 

The anthracycline quinine antibiotics daunonibicin (DNR) and doxorubicin (DOX) (Figure 5) are potent antitumor agents against a variety of human solid... 

Daunorubicin -anthracycline antitumor antibiotic DNA intercalating agent -bone marrow suppression -nausea and vomiting—mild to moderate -mucocutaneous effects (mucositis, stomatitis, diarrhea) -vesicant if extravasated —cardiotoxicity (550 mg/M2) -Liposomal daunorubicin there is significantly less bone marrow suppression, nausea and vomiting, stomatitis, and cardiotoxicity... 

Antitumor antibiotics are amongst the most important of the cancer chemodierapeutic agents, which include members of the anthracycline, bleomycin, actinomycin, mitomycin and aureolic acid families. Clinically useful agents from these families are the daunomycin-... 

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