Antazoline hydrochloride phosphate

G. Puglisi, S. Sciuto, R. Chillemi, and S. Mandiafico, Simultaneous high-performance liquid chromatographic determination of antazoline phosphate and tetrahydrozoline hydrochloride in ophthalmic solution, J. Chromatogr., 569 165 (1986). 

Mfiler J, Wolf EM. Antazoline phosphate and naphazoUne hydrochloride, singly and in combination for the treatment of allergic conjunctivitis. A controlled double-blind clinical trial. Ann Allergy 1975 35 81-86. 

Antazoline is less active than most of the other anlihisla-minic drugs, but it is characterized by the lack of local irritation. The more soluble phosphate salt is applied topically to the eye in a 0.5% solution. The less soluble hydrochloride is given orally. In addition to its use as an antihistamine, antazxtline has more than iwice the local anesthetic potency of procaine and also exhibits anticholinergic actions. 

Antistin" and many others) is an imidazoline, one of the ethylenediamine series of HISTAMINE Hi-receptor ANTAGONISTS. It is used topically for inflammation and allergic conjunctivitis, as eye-drops containing antazoline sulphate (together with the vasoconstrictor xylometazolinc hydrochloride as Otrivine-Antistin ). antazoline phosphate antazoline. antazoline sulphate antazoline. 

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