Antagonist sulpiride

Antidepressant effects Hypericum has been shown to have antidepressant effects in several animal models. An extract fraction high in naphthodianthrones showed antidepressant effects in the forced-swim test, and was attenuated by a dopamine antagonist (sulpiride) (Butterweck et... 

In another study, chemical variations of the D,/D, nonselective antagonist sulpiride (Fig. 1.20) led to the compound Do 897, a selective and potent D3 receptor partial agonist [43]. 

Mehta MA, Manes FF, Magnolfi G, Sahakian BJ, Robbins TW (2004) Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers. Psychopharmacology (in press)... 

By comparing quantal sizes from multiple cells, quinpirole has been found to reduce the average quantal size to about 51% of control values [56]. Quinpirole also decreases the maximum amperometric spike amplitude (i ), the spike width at half-height(tj/2) and the spike frequency. Each of these Dj-mediated effects on quantal size can be blocked by co-incubation in the D2 antagonist sulpiride however, exposure to sulpiride alone does not affect quantal size and the individual exocytotic event characteristics are very similar to those of controls. 

METH-induced changes in neuropeptide levels, selective Dj (SCH 23390) and D2 (sulpiride) dopaminergic receptor antagonists were coadministered. The results are expressed as percent of control to facilitate comparisons each value represents the mean SEM of five to seven animals. Data were subjeeted to either a Student s r-test (figures 4 and 5) or ANOVA analysis followed by a multiple comparisons test (figures 1, 2, and 3). Signifieanee was set at the. 05 level. 

Sulpride and sulpiride constitute another class of atypical agents. They have equivalent potency for D2 and D3 receptors, but they are also 5-HT7 antagonists. They dissociate EPS and antipsychoticefficacy. However, they also produce marked increases in serum prolactin levels and are not as free of the risk of tardive dyskinesia as are drugs such as clozapine and quetiapine. 

As opposed to the disorders of the preceding paragraph, a decrease in dopaminergic transmission may be one of the neurochemical alterations in depression (Dailly et al. 2004). The selective antagonists at D2-like receptors sulpiride and amisulpride, when given at low doses, reduce depression symptoms, presumably by blockade of D2-autoreceptors and enhancement of dopamine release (Racagni et al. 2004). Sulpiride in fact increased the release of [3H]-dopamine in human neocortex slices... 

In recent years traditional neuroleptics, as exemplified by chlorpromazine, have been structurally modified to produce drugs with greater affinity for dopamine receptors while retaining some of their activity on other receptor systems (e.g. on alpha] adrenoceptors, 5-HT2 receptors and histamine] receptors). In the non-phenothiazine series, a high degree of specificity for the D2 receptors has been achieved with sulpiride and pimozide, with haloperidol showing antagonistic effects on the 5-HT2 and alpha] adrenoceptors in addition to its selectivity for D2 receptors. The czs-(Z) isomers of the thioxanthines are potent neuroleptics that, in addition to... 

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