Anoxic depolarization

In experimental stroke, the zone of dense ischemia leads to the rapid exhaustion of substrates, particularly oxygen and glucose. The impaired energy yield cannot maintain the ion pumps so that cells loose their membrane potential (anoxic depolarization of glia and neurons). As a consequence, volt-... 

Pathophysiologically, the pronounced ADC decline during ischemia occurs at the same time as anoxic depolarization. Anoxic depolarization is the consequence of energy failure with secondary failure of ion pumps (in particular Na+/K+-ATPase), which are necessary to maintain ion gradients over cell membranes. The resulting influx of Na+-ions is accompanied by a water shift from the extra- to the intracellular space (cytotoxic edema) without a net uptake of water (Fig. 7.1). 

While this association between the ischemia-associated ADC decline and energy failure/anoxic depolarization is undisputed, it is still a matter of debate what exactly leads to the restriction in water proton diffusion. As already mentioned above, water... 

CELL DEATH ANOXIC DEPOLARIZATION METABOLIC FAILURE... 

VYSKOClL, F., KRIZ, N., and BURE , J. 1972. Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Research 39j 255-259. 

During oxidation of reduced sulfur compounds, more corrosive sulfides are produced under anoxic conditions, causing cathodic reactions. The corrosion rate increases as the reduced and oxidized FeS concentrations increase (Lee et al. 1993a, b). Cathodic depolarization processes also can yield free O2 which reacts with polarized hydrogen on metal surfaces. 

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