Anorexigenic system

Central nervous system Reduction of body weight Reduced appetite changed expression of anorexigenic (e.g., POMC) and orexigenic (e.g., NPY) hypothalamic neuropeptides... 

Yu G, Maskray V, Jackson SH, Swift CG, Tiplady B. (1991). A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects. BrJ Clin Pharmacol. 32(3) 341-45. Zelger JL, Carlini EA. (1980). Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats. Pharmacol Biochem Behav. 12(5) 701-5. 

Together with GFIB and ecstasy, amphetamines are often referred to as "club drugs," because they are increasingly popular in the club scene. They are often produced in small clandestine laboratories, which makes their precise chemical identification difficult. They differ from ecstasy chiefly in the context of use intravenous administration and "hard core" addiction is far more common with amphetamines, especially methamphetamine. In general, amphetamines lead to elevated catecholamine levels that increase arousal and reduce sleep, whereas the effects on the dopamine system mediate euphoria but may also cause abnormal movements and precipitate psychotic episodes. Effects on serotonin transmission may play a role in the hallucinogenic and anorexigenic functions as well as in the hyperthermia often caused by amphetamines. 

We also looked into the method of action ot mescaline (jf) We found when we searched for phenethylamines that mescaline is always associated with sympathomimetics and other substances which stimulate the sympathetic nervous system such as anorexigenics. 

Leptin acts on receptors in the arcuate nucleus of the hypothalamus, causing the release of anorexigenic peptides, including a-MSH, that act in the brain to inhibit eating. Leptin also stimulates sympathetic nervous system action on adipocytes, leading to uncoupling of mitochondrial oxidative phosphorylation, with consequent thermogenesis. 

Several drugs specifically stimulate the central nervous system whieh are appropriately grouped together as anorexigenic or sympathomimetic agents. 

Bupropion (amfebutamone) is a phenylisopropylaminoketone that is structurally related to the phenylisopropylamine CNS stimulant, methamphetamine, and the phenylisopropylaminoketone, cathinone (a constituent in khat), and the anorexiant, diethylpropion (Fig. 21.21). Although structurally similar to the CNS stimulants, bupropion exhibits distinctive different pharmacologic and therapeutic effects. The absence of the tricyclic ring system in bupropion results in a better adverse-effect profile than with the TCAs. The tertiary butyl group in bupropion prevents its N-dealkylation to metabolites that could possess sympathomimetic and/or anorexigenic properties. 

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