Anogeissus acuminata

AM Rimando, JM Pezzuto, NR Farnsworth, T Suntisuk, V Reutrakul, K Kawanishi. New lignans from Anogeissus acuminata with HFV-l reverse transcriptase inhibitory activity. J Nat Prod 57 896-904, 1994. 

Constit. of Anogeissus acuminata. Inhibitor of HIV-1 reverse transcriptase. Off-white powder. 

Lin T-J, Tanaka T, Nonaka G, Nishioka I, Young T-L (1991) Isolation and characterization of novel complex tannins (fiavano-ellagitannins), anogeissinin and anogeissusins A and B, from Anogeissus acuminata (Roxb ex DC.) Guill. et Peir. var. lanceolata Wall, ex Clarke. Chem Pharm Bull 39 1144-1147... 

Application of the CM reaction to natural product was demonstrated by Mori et al. in the total synthesis of anoh-gnans (258 and 259, Scheme 24.63), ° which were identified as the active HIV-1 reverse transcriptase inhibitory constituents from Anogeissus acuminata. Thus, 1,3-diene intermediate 257 of 258 was synthesized in good yield (86%) by the CM of alkyne 256 using [Ru]-II (10mol%)... 

Antiviral properties have also been described i.e., (-)-arctigenin 74 and (-)-trachelogenin 94, isolated from the tropical climbing shrub Ipomoea cairica (Convolvulaceae) (94) and the lignans 95 and 96, from Anogeissus acuminata var. lanceolata (Combretaceae) (95) exhibit strong anti-HIV properties, in vitro they inhibit the HIV-1 reverse transcriptase. 

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