Anka pigments

The retention values demonstrated that the separation of anka pigments considerably depends on the composition of the mobile phase, furthermore, it was found that the TLC... 

Fig. 2.142. Structures of anka pigments and two red nitrogen analogues. Pigments I = anakaflavin, II = monascin, HI = monascorubrin, IV = rubropunctatin, V = monascorubramine, VI = rubrop-unctatamine. Reprinted with permission from S. S. Teng el al. [315].

S.S. Teng and W. Weldheim, Analysis of anka pigments by liquid chromatography with diode array detection and tandem mass spectrometry. Chromatographia 47 (1998) 529-536. 

Six anka pigments (rubropunctatin, monascorubrin, monascin, ankaflavin, monascorubramine, rubropunctatamine) were extracted from a Monascus purpureus fermentation broth and separated on a C,g column (A = 233 nm). Elution was complete in 18 min using an 80/20 acetonitrile/water mobile phase. Pfeak shapes were broad yet well resolved. Positive identification was achieved through positive ion APCI/MS/MS [1230]. 

Heptyl prodigiosin (43) [Fig. (13)] is another antimalarial alkaloid isolated from a tunicate. Precisely, this pigment was purified from a culture of a-proteobacteria isolated from a marine tunicate and showed an antimalarial activity similar to that of quinine against the chloroquine -sensitive strain P. falciparum 3D7 with an in vitro activity that was about 20 times the in vitro cytotoxic activity against mouse lymphocytes. When this molecule was tested in vivo, a single administration of 5 mg/Kg significantly extended the survival of P. berghei ANKA strain-infected mice but, unfortunately, the same dose caused sclerotic lesions at the site of injection [62],... 

Manchand P.S., WhaUey W.B., Ghen F.-C. Isolation and structure of ankaflavin a new pigment from Monascus anka. Phytochemistry, 12 2531-2532 (1973). 

---