Anisotropine methyl bromide

Preparation of the Anisotropine Methyl Bromide To the acetone solution of the free base was added an acetone solution, containing an excess of methyl bromide. Within a few minutes the methobromide started to crystallize. The mixture was allowed to stand for several hours. The crystallized solid was filtered, and additional product was obtained by evaporation of the filtrate. 

Synonyms. Anisotropine Methobromide Anisotropine Methyl-bromide. 

Clinical studies indicate that malethamer, a crosslinked copolymer of ethylene and maleic anhydride, Tras effective in the treatment of diarrhea due to its unusual water binding capacity.Anisotropine methyl bromide (2-propylpentanoyltropinium methyl bromide) and pheno-barbital provided greater relief for various functional gastrointestinal disorders than the anisotropine alone or belladonna alkaloids with phenobarbital. 

Other drugs in this category include anisotropine methylbromide (Valpin), clidinium bromide (Quarzan also in combination with chlordiazepoxide as Librax and others), glycopyrrolate (Robinul also used parenterally in conjunction with anesthetics), isopropamide iodide (Darbid), mepenzolate bromide (Cantil), tridihexethyl chloride (Pathilon), and hexocyclium methyl-sulfate (Tral). 

---