Anisotropine methylbromide

To a hot solution of 20.6 g of sodium in 400 ml of absolute ethanol, there is added a solution of 110 g of phthalide and 110 g of p-methoxybenzaldehyde. A vigorous reaction ensues and one-helf of the alcohol is distilled off over a two hour period. Ice and water are added to the red solution end the diluted solution is ecidified with hydrochloric acid. The resulting gum solidifies end the aqueous phase is removed by decantation. The crude solid is recrystallized twice from two liters of ethenol yielding 2-(p-methoxyphenyl)-1,3-indandione as pale yellow crystals, MP155°-156°C. 

Sperber, N. U.S. Patent 2399,358 August 11,1959 assigned to Schering Corporation 

Chamical Nama endo-8,8-dimethyl-3-[(1-oxo-2-propylpantyl)oxy] -8-azoniabicyclo[3.2.1 ] octane bromide 

Common Nama Octatropine methyl bromide Structural Formula  

Trade Name Manufacturer Country Year Introduced 

Preparation of Di-n-Propy Acetyl Tropine Hydrochloride Tropine (11.12 grams) was dissolved in 100 ml of anhydrous pyridine and to this solution was added 15.64 grams of din-propyl acetyl chloride. The mixture was refluxed for 6 hours. This solution was then cooled and the pyridine removed in vacuo. The residue was dissolved in chloroform. The chloroform solution was washed with 10% hydrochloric acid to remove the residual trace of pyridine. The hydrochloride of the product ester is soluble in chloroform and is not extracted from chloroform by hydrochloric acid. This is an unexpected property. 

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Other drugs in this category include anisotropine methylbromide (Valpin), clidinium bromide (Quarzan also in combination with chlordiazepoxide as Librax and others), glycopyrrolate (Robinul also used parenterally in conjunction with anesthetics), isopropamide iodide (Darbid), mepenzolate bromide (Cantil), tridihexethyl chloride (Pathilon), and hexocyclium methyl-sulfate (Tral). 

Anisotropine methylbromide Cantharidin Dexamethasone sodium phos-... 

Anisotropine methylbromide Octatropine methylbromide CiyHs BrNO 80-50-2 362.346 cry (ace) 329 ... 

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