Anisole and Derivatives

Note According to Davis (1943), p 170, nitration of p-anisic acid yields trinitroanisole (see under Anisole and Derivatives)... 

Table 3.1 Liquid phase acetylation of anisole and derivatives (S) with acetic anhydride (AA) over zeolite catalysts. Batch reactors were employed except in References [6] and [9] (fixed bed reactor)... 

Bromination has been shown not to exhibit a primary isotope effect in the case of benzene, bromobenzene, toluene, or anisole. On the other hand, several substituted anisoles and derivatives of N,N-dimethylaniline and 1,3,5-trialkylaromatics show isotope effects. The observation of isotope effects in highly substituted systems generally seems to be the result of steric factors that can operate in two ways. There may be resistance to the large bromine taking up a position coplanar with adjacent substituents, as is required in the aromatization step. In other cases, the bulk of several substituent groups may hinder solvent or another base from assisting in proton removal. 

---