Animal models vascular tone

Animal models of diseases, as well as studies in patients with congestive heart failure, liver cirrhosis or renal insufficiency, have shown that prostanoids contribute to normal renal function by regulating vascular tone and normal blood flow (Harris, 2002 Parente and Perretti, 2003). PGE is involved in the regulation of sodium reabsorption, and its inhibition results in sodium retention that can manifest clinically in a variety of ways, such as peripheral edema, increased blood pressure, weight gain, and occasionally deterioration or heart failure. PGI increases potassium secretion and, since it has vasodilatory properties, it increases renal blood flow and glomerular filtration rate (Harris, 2002). 

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