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Animal models lead distribution

Historically, drug absorption, distribution, metabolism, excretion, and toxicity ADMET) studies in animal models were performed after the identification of a lead compound. In order to avoid costs, nowadays pharmaceutical companies evaluate the ADMET profiles of potential leads at an earlier stage of the development... [Pg.607]

Species extrapolation. Data in both animals and humans (children and adults) describing the absorption, distribution, metabolism, and excretion of lead provide the biological basis of the biokinetic model and parameter values used in the IEUBK Model. The model is calibrated to predict compartmental lead masses for human children ages 6 months to 7 years, and is not intended to be applied to other species or age groups. [Pg.249]

See other pages where Animal models lead distribution is mentioned: [Pg.225]    [Pg.238]    [Pg.6]    [Pg.37]    [Pg.81]    [Pg.285]    [Pg.118]    [Pg.2]    [Pg.13]    [Pg.256]    [Pg.765]    [Pg.5465]    [Pg.2288]    [Pg.59]    [Pg.728]    [Pg.196]    [Pg.858]    [Pg.6]    [Pg.109]    [Pg.101]    [Pg.5464]    [Pg.858]    [Pg.171]    [Pg.892]    [Pg.432]    [Pg.17]    [Pg.274]    [Pg.290]    [Pg.195]    [Pg.159]    [Pg.495]    [Pg.684]    [Pg.190]    [Pg.287]    [Pg.76]    [Pg.211]    [Pg.244]    [Pg.25]    [Pg.227]    [Pg.137]    [Pg.238]    [Pg.11]    [Pg.176]    [Pg.207]    [Pg.77]    [Pg.391]    [Pg.196]   
See also in sourсe #XX -- [ Pg.254 , Pg.271 ]



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