Animal Genome Database

Wada, Y., and Yasue, H. (1996). Development of an animal genome database and its search system. Comput. Appl. Biosci. 12, 231-235. 

Experimental infections, tissue collection, extraction conditions, purification procedures, and strategies for determining the primary structure of the natural bioactive peptides should be adapted to the animal model (size, rarity, possibility to conduct molecular biology investigations, availability of EST, and genomic databases, etc.) considered and to the complexity of the bioactive peptide. 

Gregory TR (2005). Animal genome size database, http //www.genomesize.com/. 

This chapter will discuss various experimental approaches used to select the relevant species for conduct of toxicology studies for biopharmaceuticals, as well as highlight advances made in scientific approaches and technologies to facilitate this process. Methods discussed include the traditional immunohisto-chemistry and tissue cross-reactivity studies, flow cytometry, protein sequencing, and functional in vitro assays, as well as newer approaches such as utilization of microarray databases for genomic mRNA expression data and use of transcript profiling studies as an adjunct to functional assays, to understand similarity in pharmacological responsiveness between animals and humans. 

Immunomics offers an excellent example for application of the systems biology and modern genomics/proteomics technology. Immunomics comprises a fruitful combination of modern molecular immunology, animal modeling, omics technologies, and application of ever-increasing immune databases. 

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