Perfusion cultures, animal cell bioreactors

Continuous flow operation of a bioreactor such that the cells are recycled or retained within the reactor, is sometimes known as perfusion culture. Many different kinds of devices are available for cell retention and recyele. These devices may be loeated within or outside the bioreactor vessel. External sedimentation tanks (Fig. 23b) are often used to recycle biomass in wastewater treatment processes. External and internal enhanced-rate sedimentors are also employed in animal cell culture bioreactors, as shown in Fig. 26a, b. Because of the small differences in... 

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