Aniba pseudocoto

The bark of the plants Nectandra coto (syn. Aniba coto), coto, and Ocotea pseudocoto Aniba pseudocoto), paracoto, (as well as other species of the Lauraceae) have long been known to contain biologically active secondary compounds (Geissman and Grout, 1969). The bark of these plants is used medicinally in South America. 

The mechanism for addition of two carbon units is like that of polyketide synthesis (Birch and Donovan, 1953). The starter unit is first converted to the CoA ester and C2 units added from malonyl-CoA (Fig. 10.2). The chain then cy-clizes in several ways which may be determined by the number of units added, the enzyme systems present, and other factors. Thus, one portion of the molecule is derived from shikimic acid and the other from acetate. In some cases, it is not possible to tell if a C -Cs precursor is extended by two acetate units or if a Cs-Ci precursor is extended by three units (Fig. 10.2). For example, paracotoin (3) [found in paracoto bark from Aniba pseudocoto (Lauraceae)] can be derived by either pathway (Fig. 10.3) (Manitto, 1981). After the chain is extended to six carbon atoms, cyclization occurs to produce a 6-membered lactone ring. 

From the Paracotobark or Aniba pseudocoto Rusby (Kostermans) (Lauraceae) [694,771] ... 

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See also in sourсe #XX -- [ ]

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