Angiotensinogen polymorphism

Sethi AA, Nordestgaard BG, Ager-holm-Larsen B, Frandsen E, Jensen G, Tybjaerg-Hansen A. Angiotensinogen polymorphisms and elevated blood pressure in the general population - the Copenhagen City Heart study. Hypertension 2001 37 875-881. 

In a mechanistic study of renovascular response to angiotensin II infusion, Hopkins et al. showed that the expected decrease in renal blood flow after a mild pressor dose of angiotensin II was least in TT subjects [52]. Thus, the M235T angiotensinogen gene polymorphism was associated with a blunted renovascular response. 

Winkelmann BR, Russ AP, Nauck M, Klein B, Bohm BO, Maier V, Zotz R, Matheis G, Wolf A, Wieland H, Gross W, Galton DJ, Marz W. Angiotensino-gen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. Am Heart J 1999 137 698-705. 

Tomino, Y., Makita, Y., Shike, T., et al. (1999) Relationship between polymorphism in the angiotensinogen, angiotensin-converting enzyme or angiotensin 11 receptor and renal progression in Japanese NIDDM patients. Nephron. 82, 139-144. 

Kurland L, Liljedahl U, Karlsson J, Kahan T, Malmqvist K, Melhus H, Syvanen AC, Lind L. Angiotensinogen gene polymorphisms relationship to blood pressure response to antihypertensive treatment. Results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (SILVHIA) trial. Am J Hypertens 2004 17 8-13. 

Chinese patients experience more cough from ACE inhibitors than Caucasians. A review of the pharmacokinetics and blood pressure-lowering efficacy of ACE inhibitors as well as of ACE and angiotensinogen gene polymorphism did not find significant differences between Chinese and Caucasians to account for the difference in cough incidence (43). 

Kuriyama S, Tomonari H, Tokudome G, Kaguchi Y, Hayashi H, Kobayashi H, Horiguchi M, Ishikawa M, Hara Y, Hosoya T. Association of angiotensinogen gene polymorphism with erythropoietin-induced hypertension a preliminary report. Hypertens Res 2001 24(5) 501-5. 

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