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Angiotensin agonists/antagonists

Saralasin 71 is currently in use as an angiotensin-receptor antagonist in the treatment of hypertension, despite its partial agonistic effect. The disadvantages of 71 lie in the fact that it is administered i.v. and in its short biological half-life. [Pg.136]

The AT receptors are activated by angiotensin II (All) at much lower concentrations than AIII. There are no really selective agonists, but there are many selective antagonists - a number in clinical development or use (see ANGIOTENSIN RECEPTOR antagonists). Coupling of this receptor type is to the InsPs/DAG system. The main effects of angiotensin II in the body are mediated via this receptor type. [Pg.19]

Compound 686 (PNU-97018) is an orally active nonpeptide angiotensin II receptor antagonist without any agonistic activity that has an insurmountably high antihypertensive effect <2002CPB1022, 1995JEP1042, 1995MI880>. [Pg.464]

Like angiotensin 11, non-peptide B2 receptor antagonists and agonists of bradykinin were obtained by random screening approaches. Chemical modifications on random screening leads like 101 led to non-peptide antagonists... [Pg.38]

Comparative substructural elements of peptide and nonpeptide ligands i-opioid receptor agonists, angiotensin, and NPY receptor antagonists... [Pg.589]


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Angiotensin antagonists

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