Angiogenesis homeostasis

Energy metablism Angiogenesis Iron homeostasis Cell proliferation Cell viability Inflammation... 

MPs (also called microvesicles) are present in the blood of healthy individuals and are increased in various diseases including CVD. They are small membrane vesicles derived from activated and apoptotic cells. Importantly, MPs have been proposed to play roles in thrombosis, inflammation, and angiogenesis (103). MPs are also released in the circulation (104), and ever since their potent procoagulatory properties were first recognized in the field of homeostasis (105), the interest in their potential pathophysiological importance has increased (106). MP metabolome may be a useful and reliable source of biologically relevant disease biomarkers. 

L. B. Nanney, R. M. Strieter and A. Richmond (2002). Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. / Leukoc Biol 71(1) 141-153. 

In response to hypoxia, or low oxygen levels, cells try to restore homeostasis through regulation of cellular metabolism, erythropoiesis, angiogenesis, and balancing decisions between survival and cell death [1]. As part of adaptation to their local microenvironment, most solid tumors have bypassed the normal cellular controls that regulate these processes [2]. The hypoxia-inducible factor (HIF)-la transcription factor is a master regulator of the hypoxic response in... 

In addition to being chemoattractive for specific subsets of leukocytes, chemokines often have other biological functions. Chemokines such as HCC-1 and SDF-1 may play a role in tissue homeostasis as they are expressed constitutively in many tissues and HCC-1 is present at high concentrations in normal plasma (1-10 nM). Other chemokines are known to modulate angiogenesis (16) and hematopoiesis (67). Several of the new chemokines also fall into this category and will be discussed below. The interesting development that several chemokines play a major role in HIV pathology will also be discussed below, as well as the possibility that a chemokine can act as an adhesion molecule. 

Vascular endothelial NOS (eNOS) is a calcium-calmodulin-dependent enzyme, with a monomeric molecular weight of 133 kDa that is bound to the cell membrane with a myristoylate bridge linked to the N-terminal glycine of the enzyme (Nathan 1992 Sessa et al. 1992). It is now well appreciated that eNOS is important for cardiovascular homeostasis, vessel remodeling, and angiogenesis (Nadaud et al. 2000 Chiou 2001). 

---