Angiogenesis Histology

Angiogenesis is associated with tumor development and many clinical trials have found correlations between vascular density and prognosis. Traditional analysis required biopsy and histology, with CD31 antibodies to provide blood vessel counts [393], and dyes such as India ink or Hoechst 33342 to reveal... 

Attempts to translate histological indexes of vascular density to in vivo imaging, which can be performed serially and noninvasively, have thrown additional light on the potential role of angiogenesis in malignant disease. 

Buadu, L.D., Murakami, J., Murayama, S., et al. (1997) Patterns of peripheral enhancement in breast masses correlation of findings on contrast mediiun enhanced MRI with histologic features and tumor angiogenesis. Journal of Computer Assisted Tomography, 21, 421 30. 

Fig. 11.1 Cross section of blood vessels. Small blood vessels such as capillaries, postcapillary venules and arterioles are lined by a single layer of endothelial cells (ECs), surrounded by a continuous basement membrane (BM). Pericytes (perivascular cells) surround the basement membrane, and are themselves encircled by nearby stromal fibroblasts. The BM underlies the endothelial basal lamina histologically but is biochemically indistinguishable from the reticular fiber matrix synthesized by the pericytes. (Modified from Lafleur MA, Handsley MM and Edwards DR (2003) Metalloproteinases and their inhibitors in angiogenesis, Exp. Rev. Mol. Med. 5(23) 1—39, Cambridge University Press Copyright permission granted by Cambridge University Press, 2008)...

K. Sow-Hsong, and L. Kwen-Tay. Tumor angiogenesis correlates with histologic type and metastasis in non-small cell lung cancer. Am J Resp Crit Care Med 152 2157-62, 1995. 

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