Angina pectoris, smoking

Aronow WS, Cassidy J. Effect of marihuana and placebo-marihuana smoking on angina pectoris. N Engl J Med 1974 291(2) 65-7. 

A double-blind study in 10 smokers with angina pectoris, taking daily doses of either propranolol 240 mg, atenolol 1 (X) mg or a placebo, found that smoking r uced their plasma propranolol levels by 25% when compared with a non-smoking phase. Plasma atenolol levels were not significantly altered. Both of the beta blockers reduced heart rate at rest and during exercise, but the reductions were less when subjects smoked (effects attenuated by 8 to 14%). ... 

Study of 110 cases of angina pectoris plasma concentrations of vitamin C, E and carotene were significantly inversely related to the risk of angina pectoris. However, the relation of vitamin C to risk was substantially reduced after adjustment for smoking. Only vitamin E remained inversely related to the risk of angina (Riemersma a/., 1991). 

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