Androst-4-ene-3,ll,17-trione

Androst-4-ene-3,ll,17-trione, 88, 377, 409 di-Androst-5-en-3/3-oI, 199 Androst-5-en-17-ol-3-one, 32 Androst-l-en-3-one, 152 Androst-4-en-3 -one, 152 5a-Androst-8-en-l 1-one, 189 5 -Androst-8(14)-en-15-0ne, 155 Anhydrous hydrogen fluoride, 425 Aqueous hydrogen fluoride, 435 Argentic picolinate, 241 17a-aza-D-homo-estrone methyl ether, 163... 

Adrenosterone (Reichstein s G, androst-4-ene-3,ll,17-trione) [382-45-6] M 300.4, m 214-217 , 220-224 , 224-226 , [a] 1 +364 (c 0.18, EtOH). Dissolve adrenosterone in Me2CO, decolorise it with charcoal, filter, add H2O, Me2CO evaporate and the solid is recrystallised from aqueous EtOH. Also recrystallise it from Et20 or Et20/pentane and dry it at 110 /0.1mm for 2hours. It can be sublimed und high vacuum. [Reichstein Helv Chim Acta 20 953, 979 1937, Mason et al. J Biol Chem 116 267 1936, Beilstein 7 III 4601.]... 

Jervine, one of the most readily available Veratrum alkaloids, was the starting material for the synthesis of C-nor-D-homo steroid hormone analogs. Kupchan and Abu El-Haj (31) degraded jervine to the 3 8-hydroxy-14(1312 8-H)-a6eo-androst-5-ene-ll,17-dione (28) and prepared 17a-hydroxy-14(13 12)3H)-a6eo-pregn-4-ene-3,ll,20-trione (29) and its 17(8-isomer (30). 

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