Andros tenedione

F M Andros tenedione Inhibits above effects prevents premature milt release Sorensen and Stacey, 1999... 

A4-3-Ketones react easily with ethylene glycol or other glycols in the presence of p-toluenesulfonic acid to give 3-ketals with migration of the 4,5-double bond to the 5,6-position.57 With 19-nor-A4-3-ketones a mixture of A5(6)-and A5(10)-enes is obtained.190 In this series selectivity is achieved only in the presence of the 17-ketone when exchange dioxolanation is used.32 Andros-tenedione has also been converted into the 3-monoketal by initial protection of the 17-ketone as the cyanohydrin.52 Similarly, the 3-monoketal (34) has... 

Androstene-3,17-dione can be transformed selectively into the 17-ethylenehemithio acetal in the presence of the a,P-unsaturated carbonyl system. The parent andros-tenedione can be regenerated by treatment of the hemithio acetal with Raney Ni (eq. 13.82) by the reaction of eq. 13.79.160... 

Andros tenedione testosterone Nocardia opaca DCP1P (amp.) 0.0015-0.1 Wollenberger et al. (1980b)... 

In Table 2 the major metabolites of the steroid sex hormones and some important related steroids are listed. Their relationships to their precursors are in some cases controversial at present and will be discussed in the next section of this article. Suffice it to say at the moment that simple relationships between the excretion rates of some of these metabolites and the secretion rates of their precursors are not easy to establish. On the other hand, it is fair to add that some of the complexities implied by recent work on the metabolism of testosterone and andros-tenedione, and on the metabolic activity of the placenta and fetus in pregnancy should not be allowed to obscure the relative simplicity of many aspects of the metabolism of progesterone and of estrogens. 

A series of 4-thioethers were synthesized as substrate analogues of andros-tenedione with alkyl, aralkyl and aryl side-chains. The K, values of this series varied from 36 to 73 nM (K (androstenedione) = 53 nM) and allowed a structure-activity relationship to be determined for the 4-thioethers. A delineation of the available volume around this region of the substrate was proposed as a tight enzyme pocket that can accommodate substituents up to 5.5 A in length [174]. 

---