Anchor fragment

Hydrazide 1 was designed as the CA anchor fragment and hence necessitated dual functionality an Ar-SO NH moiety for reliable CA affinity and a hydrazide moiety to take part in hydrazone exchange. Hydrazide 2 lacked the sulfonamide moiety of 1, but was still able to participate in hydrazone exchange and thus functioned as a control compound. Fragments A-E, the exchange partners for 1 and 2, were selected to introduce an array of tails onto 1 to enable exploration of periphery recognition interactions with CA. 

Scheme 7.3 (a) Anchor fragments equipped with two thiol moieties (F-J). (b) Thiol partner fragments (4-22). (c) DCC ntilizing thiol-disulfide exchange and targeting metallo-P-lactamase (Bell). 

The reaction between Os3(CO),2 and silica and alumina has been the object of different studies. Appropriate thermal treatment under argon of the OssjCOjn initially physisorbed leads to [Os3(CO)io( t-H)( t-OSi)] or [Os3(CO)io(n-H)(p-OAl)] surface species that are similar to those obtained from RusjCOjn [129, 130]. An increase of temperature can produce osmium oxidation by the hydroxyl groups and the breaking of the Os-Os bonds, resulting in a surface carbonyl species of Os(II), Os (CO) ( = 2 or 3), surface anchored fragments that in the case of alumina have been characterized by EXAFS [131, 132]. 

Figure 7.14 Deconvoluted ESI mass spectra from an equimolar mixture of 19 thiols

Incremental construction algorithms typically consist of three steps 1) selection of a set of anchor fragments, 2) placement of the anchor fragments within the active site, and 3) the incremental construction phase. Several fragments of the ligand can serve as the anchor fragment for subsequent construction. Moon and Flowe had... 

Figure 2 The anchor fragment is selected as the rigid overlapping fragment with the largest number of heavy atoms.

SLIDE In FB SLIDE, Anchor fragments are chosen which contain triplets of mps of which one 18... 

This concept was first applied for hydroformylation in 2002 by Mehnert at ExxonMobil [50]. This work involves a surface of a support material (silica gel) that is modified with a monolayer of covalently anchored fragments of l-n-butyl-3-[3-(triethoxysilanyl)propyl]imidazolium. Treatment of this surface with additional IL results in the formation of a multiple layer of free ionic liquid which serves as... 

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