Anchinoe tenacior

A sulfone (636) is a minor constituent of the Mediterranean sponge Anchinoe tenacior [502]. Sulfolane (637), a familiar industrial chemical, was isolated from a mixture of the sponge Batzella sp. and a Lissoclinum tunicate from Victoria, Australia [503]. It is possibly an absorbed compound rather than a natural product [12]. 

A sulfone group incorporated within a l,l-dioxo-l,4-thiazine ring is also present in 6-(p-hydroxyphenyl)-2i/-3,4-dihydro-l,l-dioxo-l,4-thiazine (286), a compound obtained from the sponge Anchinoe tenacior [211], and in euthyroideones A-C (287-289), which are brominated quinone methides isolated from the New Zealand bryozoan Euthyroides episcopalis (order Cheilostomatida, suborder Ascophotina, family Euthyroididae) [212]. The spectral data of euthyroideone A (287), secured by X-ray analysis, was used for the structural determination of euthyroideones B (288) and C (289). Compound 288 showed a weak cytotoxic activity towards the BSC-1 cell line. 

Anchinopeptolides Anchinoe tenacior (Mediterrranean SRIF-R ligands (B2-R,... 

Anchinopeptolides A-D Anchinoe tenacior Ligands of somatostatin, bradykinin and neuropeptide Y receptors... 

The sulfone group is relatively rare in natural products, but a simple example is the l,4-thiazine-l,l-dioxide 10 (Figure 2), isolated from the marine sponge Anchinoe tenacior (94TL2421). The structure was assigned on the basis of NMR spectroscopy, but has yet to be confirmed by S5mthesis. 

Casapullo, A., Finamore, E., Minale, L., ZoUo, F., (1993). A dimeric peptide alkaloid of a completely new type, anchinopeptohde A, from the marine sponge Anchinoe tenacior. Tetrahedron Lett. 34,6297-6300. 

Anchinoe tenacior Casapullo, Minale, and Zollo, 1994a... 

Casaprrllo, A., Minale, L., and Zollo, F. (1994b) Four new dimeric peptide alkaloids, anchinoepeptobdes B-D, and cycloanchino-epeptobde C, congeners of anchinoepeptolide A, from the Mediterranean marine sponge Anchinoe tenacior. J. Nat Prod., 57, 1227-1233. 

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