Anatomic Localization of PPT Gene Products

5 pmolg tissue (Lilly et al., 1994), a level similar to that found in guinea-pig trachea (approximately 

Substance P content has been shown to be present at high levels in nerves subtending inflamed organs or tissues. For example, an inflammatory cytokine, interleukin 1 8 (IL-1/3), has been found to elevate substance P content and PPT-I mRNA expression in rat superior cervical ganglion cells in culture (Jonakait et al., 1991). This eflFect has also been documented in vivo-, increased levels of PPT-I mRNA and substance P product have 

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