Analytical development, goals

Ministry of Education and Science of Russia in framework of the Analytical departmental goal program Development of scientific potential of higher school (2009-2010) , (project No 2.1.2/1056). 

An analytical development program for biomolecules such as proteins comprises in-depth product characterization, assay development, and routine testing activities (Chapter 8). The goals of characterization efforts are to define the... 

The development of fiber optics technology, user-friendly displays, and enhanced data presentation capabihties have made on-line analysis acceptable within the plant manufactuting environment. However, it is apparent that a barrier stiU exists to some extent within many organizations between the process control engineers, the plant operations department, and the analytical function, and proper sampling is stiU the key to successful process analytical chemistry. The ultimate goal is not to handle the sample at ah. 

The development of rapid, accurate, and noninvasive online measurement sensors and instraments is a high-priority goal in the commercialization of biotechnology (Figure 3.4). Some of these instraments will build on analytical methods now used in catalysis and other surface sciences, such as... 

New developments are, however, needed to make a major step forward in the field of speciation analysis. The first part, isolation and separation of species, may be the easiest one to tackle. For the second part, the measurement of the trace element, a major improvement in sensitivity is needed. As the concentration of the different species lies far below that of the total concentration (species often occur at a mere ng/1 level and below), it looks like existing methods will never be able to cope with the new demands. A new physical principle will have to be explored, away from absorption spectrometry, emission spectrometry, mass spectrometry, and/or more powerful excitation sources than flame, arc or plasma will have to be developed. The goal is to develop routine analytical set-ups with sensitivities that are three to six orders of magnitude lower than achieved hitherto. 

Intensified metabolic control, especially in case of diabetes, demands minimal-invasive or non-invasive methods of analytical measurement. For this goal, a method has been developed to measure the blood glucose content in vivo, in direct contact with the skin, by means of diffuse reflection near infrared (NIR) spectroscopy on the basis of multivariate calibration and neural networks (Muller et al. [1997] Fischbacher et al. [1997] Danzer et al. [1998]). Because no patients with any standard blood glucose value are available in principle, a method of indirect calibration has... 

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