Analytical chemistry applications, cyclodextrins

Dodziuk H (2006) Cyclodextrins and their complexes chemistry, analytical methods, applications. Wiley-VCH Verlag GmbH Co, Weinheim... 

Li, S., Purdy,WC. Cyclodextrins and their applications in analytical chemistry,... 

Enzymatic process is the main method to produce cyclodextrins (CDs), and so far, chemical methods have been reported. CD is industrially produced from starch, glucogen, malto-oligosaccharides, and other dextrins through catalysis by cyclodextrin glucosyl transferase (CGTase). More and more researchers focus on the essential CGTase to prepare CD due to its wide applications in food, medicine, cosmetics, environmental protection, and analytical chemistry. 

Approximately 25% of the CD literature involves the applications of cyclodextrins in analytical chemistry and diagnostic preparations. The analytical applications of CDs refer mainly to the application of cyclodextrins in gas chromatography, in high-performance liquid... 

Cyclodextrins (and their derivatives) have been used widely in analytical chemistry, in particular, in separation technology. They have been incorporated into chromatographic applications, such as thin layer chromatography, gas chromatography, capillary electrophoresis and high performance liquid chromatography (HPLC), for the separation of similar chemical substances and even enantiomers (cyclodextrins are chiral). Conventional chiral HPLC columns are costly. A normal column containing an immobilised chiral cyclodextrin, such that one enantiomer forms a more stable complex over the other, can drastically reduce the cost. 

Dodziuk H. Cyclodextrins and Their Complexes. Chemistry, Analytical Methods, Applications. Wiley-VCH London 2006. 

Figure 6 Structure of p-cyclodextrin. Reprinted with permission from Li S and Purdy WC (1992). Cyclodextrins and their applications in analytical chemistry. Chemical Reviews 92 1457-1470. Copyright (1992) American Chemical Society.

Roa Morales G, Ramirez Silva MT, Romero Romo MM, Galicia L (2005) Heavy metal determination by anodic stripping voltammetry with a carhon paste electrode modified with alpha -cyclodextrin. In Palomar M (ed) Applications of Analytical Chemistry in Environmental Research, Research Signpost, Trivandrum, India... 

Chiral separations performed with capillary electrophoresis is an ever growing branch in the field of analytical chemistry. More applications originate both in aqueous and in nonaqueous environments, and most likely, cyclodextrins will continue to be the most popular selectors. 

Tang, B, L Ma, HY Wang and GY Zhang (2002). Study on the supramolecular interaction of curcumin andbeta-cyclodextrin by spectrophotometry andits analytical application. Journal of Agriculture Food Chemistry, 50(6), 1355-1361. 

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