Analysis of Pharmacokinetic Data

G. S. Klonicki, Using SAS/ETS Software for Analysis of Pharmacokinetic Data. SAS Institute Inc., Cary, NC, 1993. 

J. Powers, Statistical analysis of pharmacokinetic data. J. Vet. Pharmacol. Therap., 13 (1990) 113-120. 

Two classical methods used in the analysis of pharmacokinetic data are the fitting of sums of exponential functions (2- and 3-compartment mammillary models) to plasma and/or tissue data, and less frequently, the fitting of arbitrary polynomial functions to the data (noncompartmental analysis). 

Hattis, D., L. Erdreich, and M. Ballew. 1987. Human variahility in susceptibility to toxic chemicals - A preliminary analysis of pharmacokinetic data from normal volunteers. Risk Anal. 7 415 26. 

Moments of a function will play an essential role in estimating specific pharmacokinetic parameters. The modern use of moments in the analysis of pharmacokinetic data and the notions of noncompartmental or integral equation analysis can be traced to Yamaoka et al. (10), although these authors correctly point out that the formulas were known since the late 1930s. 

Peck, C.C. Sheiner, L.B. Nichols, A.I. The problem of choosing weights in non-linear regression analysis of pharmacokinetic data. Drug Metab. Rev. 1984,15, 133-148. 

Regression analysis of pharmacokinetic data from patients has suggested that co-administration of caspofungin with inducers of drug metabolism and mixed inducer/inhibitors, namely carbamazepine,... 

The noncompartmental analysis of pharmacokinetic data after extravascular drug administration, when coupled with that of IV dosing, can yield additional relevant pharmacokinetic parameters, particularly regarding absorption processes. For example, the systemic availability F), which represents the net fraction of the drug dose reaching the systemic circulation after extravascular administration, is defined as ... 

Jusko W J (2005). Guidelines for collection and analysis of pharmacokinetic data. In M Leslie, J J Schentag, W E Evans, et al. (eds.). Applied Pharmacokinetics Pharmacodynamics Principles of Therapeutic Drug Monitoring Applied Therapeutics, Inc., Vancouver, Canada, Chapter 2. 

There are four main study objectives for analysis of pharmacokinetic data (1) to summarize the kinetics of the drug (descriptive pharmacokinetics), (2) to quantify one or more kinetic processes of the drug, (3) to explain the pharmacokinetics, or... 

Craigmill AL, Miller GR, Gehring R, Pierce AN, Riviere JE, Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank Oxytetracycline and procaine peniciUin G, J. Vet. Pharmacol. Ther. 2004 27 343-353. 

A study in 14 HIV-positive patients given atovaquone 750 mg every 12 hours and zidovudine 200 mg every 8 hours found that under steady-state conditions the zidovudine had no effect on the pharmacokinetics of atovaquone. This confirmed the findings of a previous analysis of pharmacokinetic data from a small number of patients enrolled in clinical studies. However, the AUC of the zidovudine was increased by about 30%, and its clearance was reduced by 25% by the concurrent use of atovaquone. ... 

Kilby JM, Hill A Buss N. The effect of ritonavir on saquinavir plasma concentration is independent of ritonavir dosage combined analysis of pharmacokinetic data from 97 subjects. HIV Med (2002) 3, 97-104. 

In a retrospective analysis of pharmacokinetic data from phase I studies, the mean maximum concentration and AUC of frovatriptan were 25% and 30% higher, respectively, in women taking oral contraceptives than in women not taking oral contraceptives. ... 

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