Analysis maitotoxin

The extreme toxic potential of marine metabolites often prevents their application in medicine. However, a number of metabolites proved to be valuable tools in biochemistry, cell and molecular biology. For instance the neurotoxic maitotoxin [109-112] (interaction with extracellular calcium enhancement of calcium influx [113]), the neurotoxic brevetoxin B [114] (interaction with the binding-site-5 of voltage-sensitive sodium channels [115]), tetrodotoxin and saxitoxin (voltage clamp analysis to study sodium channels and excitatory phenomena [116] tetrodotoxin abolishes brevetoxin B activity [117]), okadaic acid [118-120] (analysis of phosphorylation and dephosphorylation processes in eukaryotic cell metabolism [121]), and palytoxin (stimulation of arachidonic acid metabolism synergistically with TPA-type promoters [122]). 

G. to V j that produces ciguatoxin precursors (142—147) and maitotoxin (148). The absolute stereochemistry of gambieric acids A-D (149-152) were assigned by the modified Mosher s method, conformational analysis based on J values and NOE correlations, chiral fluorimetric HPLC analysis, and synthesis of A/B-ring models of gambieric acids A-D (149-152). ... 

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