Analogy with Medicinal Chemistry

Designating property-based guidelines for designing chemicals such that they are minimally absorbed and, therefore, should be less toxic, is analogous to a known phenomenon in medicinal chemistry - designing drug compounds such that they are likely to be well absorbed into the body to optimize the desired pharmacological effect. 

Do Chemicals with Similar Toxicity Profiles Have Similar Physical/Chemical Properties  

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The Corey-Chaykovsky reaction incited some applications in medicinal chemistry. During the synthesis of analogs of fluconazole, an azole antifungal agent, treatment of 49 with 1 led to the corresponding epoxide, which was subsequently... 

The potential utility of peptides as therapeutic agents with clinical applications is limited as a consequence of intrinsic peptide properties such as metabolic instability or poor transmembrane mobility. Hence, the design and synthesis of meta-bolically stable peptide analogs that can either mimic or block the bioactivity of natural peptides or enzymes is an important area of medicinal chemistry research. Numerous structural modifications to peptides have been examined in pursuit of molecules with more desirable properties [1-3]. These modified structures, peptidomimetics, are nonpeptide molecules that imitate the desired properties of the natural substances. 

Starting from bioactive proteins, peptides with similar activity or binding properties could frequently be identified the development of peptide mimetks from those peptides is a classical exercise in medicinal chemistry. The analogous approach for carbohydrates, the development of carbohydrate mimetks from bioactive polysaccharides, is in its infancy. 

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