Analgesic nephropathy Australia

In Belgium, the distribution of analgesic nephropathy in patients with terminal renal insufficiency was well correlated with the sale of drugs containing either aspirin -I- phenacetin or paracetamol + caffeine (SEDA-7,75), and it is estimated that Belgium, after Australia, had the second highest incidence of analgesic nephropathy in the world. 

Detailed information concerning the extent of the problem of analgesic nephropathy is limited, particularly for recent years. National annual data were collected in Australia/New Zealand by the Aushalian and New Zealand Dialysis and Transplant Registry (ANZDATA) [51] and in the United States by the United States Renal Data System (USRDS) [52]. In Eu-... 

Figure 2. Incidence of analgesic nephropathy (AN) in Australia 1971-2005. B. Incidence of AN in Belgium 1970-1998 and in Flanders 1994-2006. At the bottom, absolute numbers of new AN.

Nanra RS, Stuart-Taylor J, De Leon AH, White KH. Analgesic nephropathy etiology, clinical syndrome, and clinicopathologic correlation in Australia. Kidney Int 1978 13 79-92. 

NSAIDs block the synthesis of COX products of arachidonic acid, which have a critical role in renal hemodynamics, control of tubular function, and renin release. It is now apparent that two isoforms of COX synthesize prostaglandins. COX-1 is a resident or constitutive form and COX-2 is an inducible form that increases with disorders of inflammation. NSAIDs are nonspecific inhibitors of both COX isoforms. Analgesic nephropathy is a common cause of ESRD in a number of countries, reaching 10% in Switzerland and Australia, but is essentially a preventable condition for which biochemical monitoring has proved useful. The incidence of this disease has decreased over the last decade as awareness has improved and phenacetin was withdrawn from over-the-counter analgesic mixtures. In the United States, 1 in 5 citizens (50 miflion) report that they use an... 

Kincaid-Smith P. Analgesic nephropathy in Australia. Contrib Nephrol 1979 16 57-64. 

Analgesic nephropathy is the most serious complication of analgesic abuse, and this condition accounted for 29% of a series of patients with the end-stage renal failure in New South Wales, Australia (6 ). There appears to be marked geographical variation in... 

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