Amyloid diseases emergence

S. E. Radford and C. M. Dobson. From computer simulations to human disease emerging themes in protein folding. Cell, 97 (1999), 291 M. Bucciantini, E. Giannoni, F. Chiti et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature, 416 (2002), 507 M. Dumoulin, A. M. Last, A. Desmyter et al. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature, 424 (2003), 783 F. Chiti, M.Stefani,... 

Amyloid in the original medical sense of the term refers to certain disease-related protein aggregates (Westermark et al., 2005). Nowadays, it is applied more broadly to protein aggregates that have certain biophysical and biochemical properties in common. The original amyloids have been found to consist mainly of polymerized fragments of about 20 different proteins, each amyloid containing one of these polypeptides. More recently, it has emerged that many other proteins may be converted into amyloid artificially under in vitro conditions that involve prior denaturation (Chiti et al., 1999 Stefani and Dobson, 2003). 

Emerging Drugs and Targets for Alzheimer s Disease Volume 1 Beta-Amyloid, Tau Protein and Glucose Metabolism... 

LukiwWJ (2012) Amyloid beta(AP) peptide modulators and other current treatment strategies for Alzheimer s disease (AD). Exp Opin Emerg Drugs. doi 10.1517/14728214.2012.672559... 

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