Camelid antibodies

S. E. Radford and C. M. Dobson. From computer simulations to human disease emerging themes in protein folding. Cell, 97 (1999), 291 M. Bucciantini, E. Giannoni, F. Chiti et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature, 416 (2002), 507 M. Dumoulin, A. M. Last, A. Desmyter et al. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature, 424 (2003), 783 F. Chiti, M.Stefani,... 

Camelid Unique antibodies from members of the Camelidae family. The antibody... 

Lipovsek, D., Lippow, S. M., Hackel, B. J., Gregson, M. W., Cheng, P., Kapila, A. and Wittrup, K D. (2007) Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display molecular convergence with single-domain camelid and shark antibodies. J Mol Biol 368, 1024-1041... 

Figure9.3 Schematic depiction of (a) natural antibodies with single-chain variable fragment, antigen-binding Ig fragment, and (b) camelid heavy-chain IgC with the variable fragment HH. Random or oriented immobilization is represented at the bottom of the figure (Reprinted with permission from [13], published by The Royal Society of Chemistry)...

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