AMPS-DodMAm copolymers

Figure 6. Relaxation time distributions for the AMPS-DodMAm copolymers...

Figure 7. Relaxation time distributions for the AMPS-DodMAm copolymers with yi>od = 2.5 and 10 mol % at 10.0 g/L in 0.1 M NaCl at varying...

Figure 9. The /3//1 ratio for the pyrene-labeled AMPS-DodMAm copolymers in 0.1 M NaCl as a function of bod ...

Hydrophobic functional-molecules can be incorporated into the higher-order unimer micelles either via chemical bonding of the functional molecules to amphiphilic polymers or by physically solubilizing tiie mol ules into the unimer micelle. For example, when an AMPS-DodMAm copolymer and a hydrophobic small-molecule are dissolved together in ethanol, and the ethanol solution is poured into excess water, then the hydrophobic molecules can be entrapped in a hydrophobic microdomain during the process of the hydrophobic self-association of polymer-bound dodecyl groups. However, it is practically difficult to precisely control the number of the sm l... 

Figure 12. Electropherograms for the AMPS-DodMAm copolymers with varying/bod measured in a borate buffer (pH = 9.03, ionic strength 0.05).

Hydrophobic associations in random copolymers of AMPS and iV-d ecylmethacrylamide (DodMAm) were investigated by viscometry, QELS, capillary electrophoresis (CE), NMR relaxation, and various fluorescence techniques (24,48), For fluorescence studies, the polymers that are singly-labeled with pyrene or naphthalene or doubly-labeled with pyrene and naphthalene (Chart 2) were employed (48). In this section, the self-association behavior of AMPS-DodMAm co lymers in water will be discussed with a focus on intra- and interpolymer self-associations as a function of the DodMAm content (/bod) in Ae copolymer. 

Not only the copolymers of AMPS and DodMAm but also the copolymers of AMPS and a methactylamide A -substituted with cyclododecyl, adamantyl, or naphthylmethyl groups (Chart 3) form either a unimolecular flower-like or higher-order micelle (i.e., tertiary structure) depending on the hydrophobe content in die copolymer. An important feature for these copolymers is that such unimer micelles are formed even at hi polymer concentrations in water. Some of the requiate structures for polymers to form unimer micelles are (i) the hydrophobes should be sufficiently bulky, (ii) the sequence distribution of hydrophobic and electrolyte monomer units should be random, and (iii) the hydrophobes should be linked to the polymer main chain via amide spacer Ending (22). 

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