Amphetamine striatal dopamine receptor

Imaging studies have shown increased amphetamine-induced striatal dopamine release, increased baseline occupancy of striatal D2 receptors by extracellular dopamine, and other measures consistent with increased striatal dopamine synthesis and release. 

Wagner et al. (1980) found that treating rhesus monkeys with amphetamine leads to a long-lasting loss of dopamine and dopamine uptake sites (receptors). Juan et al. (1997) confirmed that amphetamine produces a depletion of striatal dopamine that is measurable on autopsy of mice at 5 days and 2 weeks (the final experiment). The animals were administered four doses of 10 mg/kg spaced 2 hours apart. 

Konradi C, Leveque JC, Hyman SE (1996) Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J Neurosci 76 4231-4239. 

Schmidt, C.J., Sullivan, C.K., and Fadayel, G.M., Blockade of striatal 5-hydroxytryptamine2 receptors reduces the increase in extracellular concentrations of dopamine produced by the amphetamine analogue 3,4-methylenedioxymethamphetamine, J. Neurochem. 62(4), 1382-1389, 1994. 

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