Amphetamine hydrochloride

PREPARATION OF STANDARDS. For the amphetamine standard, 126 mg of amphetamine hydrochloride are dissolved in 100 cm3of water. This is equivalent to 1 mg/cm3 of amphetamine. To 5 cm3 of the amphetamine solution is added 0.5 cm3of 20% KOH. After extraction with 5 cm3 of diethyl ether, this is diluted 1 10 with ether, giving a 0.1 mg/cm3 solution of amphetamine. 

The last of the butyl isomers, the tert-butyl compound, was made from a much more obvious starting material. This is the commercially available tert-butyl hydroquinone. It was methylated in sodium hydroxide with methyl iodide, and then carried through the above sequence (benzaldehyde. mp 124 °C from cyclohexane, nitrostyrene, yellow crystals from methanol, mp 95-96.5 °C, and lithium aluminum hydride reduction) to give 2,5-dimethoxy-4-(l,l-dimethylethyl)amphetamine hydrochloride (DOTB, mp 168 °C). Rats trained in a process called the Sidman Avoidance Schedule gave behavior that suggested that DOTB had no activity at all, and in human trials, doses of up to 25 milligrams were totally without effect. 

NaOH, and extracted with 4x100 mL CH2C12. Removal of the solvent under vacuum yielded 3.5 g of a viscous off-white oil that was distilled at 160 °C at 1.3 mm/Hg to give 2.0 g of a white viscous oil. The pot residue remained fluid, but was discarded. This distillate was dissolved in 8.0 mLIPA to give, eventually, a clear solution. This was neutralized with concentrated HC1 and diluted with 100 mL anhydrous EtjO. The loose white crystals of 3,4-methylenedioxy-N- (2-hydroxy-ethyl)amphetamine hydrochloride (MDHOET) that formed were removed by filtration, washed with Etp, and air dried. These weighed 2.3 g, and had a mp of 147-148 °C. Anal. (C 2H,8C1N0,) N. 

Fig. 9. Infra-red spectra of A, amphetamine base B, amphetamine hydrochloride C, amphetamine mandelate ...

Amobarbital if-Amphetamine hydrochloride Carbocaine hydrochloride Carbon disulfide Dynacaine hydrochloride... 

Many drugs, including quinine, codeine, caffeine, and amphetamine, are amines. Like other amines, these substances are weak bases the amine nitrogen is readily protonated upon treatment with an acid. The resulting products arc called add salts. If we use A as the abbreviation for an amine, the acid salt formed by reaction with hydrochloric acid can be written AH Cl. It can also be written as A-HCI and referred to as a hydrochloride. Amphetamine hydrochloride, for example, is the acid salt formed by treating amphetamine with HCk... 

Toxic impurities are those that have a significant undesirable biological activity even at low concentrations and require identification and quantification by specific tests. They may arise from the synthesis, preparation, or degradation of the drug. An example of a toxic impurity is amphetamine hydrochloride in phenylpropanolamine hydrochloride, which the USP limits to 0.001%. 

Figure 2 Raman spectra from drugs of abuse cocaine, amphetamine, hydrochloride, and dia-morphine. (one accumulation of 120 sec, 785-nm excitation).

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