AMPA receptor binding

Stcnsbpl, T. B Madsen, U., and Krogsgaard-Larsen, P. (2002) The AMPA receptor binding site focus on agonists and competitive antagonists. Curr. Pharm. Design 8, 857-872. 

Dracheva S, McGurk SR, Haroutunian V. 2005. mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics. J Neurosci Res 79 868-878. 

Healy DJ, Haroutunian V, Powchik P, Davidson M, Davis KL, et al. 1998. AMPA receptor binding and subunit mRNA expression in prefrontal cortex and striatum of elderly schizophrenics. Neuropsychopharmacology 19 278-286. 

Noga JT, Hyde TM, Bachus SE, Herman MM, Kleinman JE. 2001. AMPA receptor binding in the dorsolateral prefrontal cortex of schizophrenics and controls. Schizophr Res 48 ... 

Noga JT, Wang H. 2002. Further postmortem autoradiographic studies of AMPA receptor binding in schizophrenia. Synapse 45 250-258. 

Srivastava S, Ziff EB. 1999. ABP A novel AMPA receptor binding protein. Ann N YAcad Sci 868 561-564. 

AMPA receptors bind glutamate, AMPA, and quisquaUc acid. 

Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB (1998) Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Nemon 21 581-591. 

The kainate receptors are composed of subunits from the GluR5-GluR7 class and the KA1-KA2 class of subunits. Homomeric receptors of the former class generate functional receptors and bind kainate with an affinity of 50 to 100 nM. KA1 or KA2 do not generate functional channels, but the receptors bind kainate with an affinity of 5 to 10 nM. Homomeric GluR6 and KA2 receptors are neither activated by AMPA, nor do they bind AMPA. Interestingly, when they are co-expressed, heteromeric receptors respond to AMPA. 

Hogner, A., Kastrup, J. S Jin, R., Liljefors, T Mayer, M. L., Egebjerg, J., et al. (2002) Structural basis for AMPA receptor activation and ligand selectivity crystal structures of five agonist complexes with the GluR2 binding core../. Mol. Biol. 322,93-109. 

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