Pirenzepine Amoxicillin

Deppermann K-M, Lode H, HofQ en G, Tschink G, Kalz C, Koeppe P. Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline and amoxicillin-clavulanic acid. Antmdcrob Agents Chemodier( 9Z9) 33,1901-1907. 

Aspirin, indometacin, phenylbutazone, sulfaphenazole and sulfinpyrazone prolong the half-Ufe of benzylpenicillin whereas chlorothiazide, sulfamethizole and sulfamethoxypyridazine do not. Some sulfonamides reduce oxacillin blood levels. Pirenzepine does not affect the pharmacokinetics of amoxicillin. 

Pirenzepine 50 mg given three times daily on the day before and with a single 1-g dose of amoxicillin had no significant effect on the pharmacokinetics of the antibacterial. ... 

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