Amoxicillin, functional groups

Enzymatic deacylation of penicillin G 39 by penicillin G acylase can be run in water at room temperature and does not require protection or deprotection of other functional groups present in the molecule (Figure 14.15). Immobilized penicillin acylase was then used to catalyze acylation of 6 APA 40 and 7 ADGA to produce a range of semisynthetic (3 lactam antibiotics such as ampicillin 41 and amoxicillin 42 [21]. 

Draw for yourself the structures of amoxicillin and Tamiflu shown on page 10 of the textbook. Identify on your diagrams the functional groups present in each molecule and the ring sizes. Study the carbon framework is there a single carbon chain or more than one Are they linear, branched, or cyclic ... 

Potential for Other Antibiotics The SLMs also have the potential for the removal and recovery of other antibiotics, including Cephalexin, Ampicillin, and Amoxicillin. Cephalexin is in the cephalosporin class of antibiotics, and it is one of the most prescribed antibiotics, approximately 3000 tons/year worldwide (Sheldon, 2004). The cephalosporin molecules contain acid and amine functional groups, which are amendable for complexation with extractants incorporated in liquid membranes. Studies on the... 

Triple therapy with bismuth plus amoxicillin and metronidazole for 2 weeks has been compared with dual therapy with omeprazole plus amoxicillin for 2 weeks in 126 patients over the age of 60 years, who were H. pylori positive and had functional dyspepsia (16). Eradication rates were similar in the two groups 2 months after the end of therapy (66% with triple therapy and 64% with dual therapy), and there was a significant reduction in dyspeptic symptoms in patients... 

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