Amorphous solids isotherm analysis

Pham TN, Watson SA et al (2010) Analysis of amorphous solid dispersions using 2D solid-state NMR and IH T 1 relaxation measurements, vol 7. ACS Publications, New York, pp 1667-1691 Pikal MJ, DeUerman KM (1989) Stability testing of pharmaceuticals by high-sensitivity isothermal calorimetry at 25 C cephalosporins in the solid and aqueous solution states. Int J Pharm 50 233-252... 

Liu J, Rigsbee DR, Stotz C, Pikal MJ (2002) Dynamics of pharmaceutical amorphous solids the study of enthalpy relaxation by isothermal microcalorimetry. J Pharm Sci 91(8) 1853-1862 Liu H, Zhang X, Suwardie H, Wang P, Gogos CG (2012) Miscibility studies of indomethadn and Eudragit E PO by thermal, rheological, and spectroscopic analysis. J Pharm Sci 101(6) 2204-2212... 

The crystallization kinetics of amorphous materials can be investigated either isothermally or non-isothermally by using thermal analysis techniques. In the isothermal method, the sample is heated above the glass transition temperature and the heat absorbed during the crystallization process is measured as a function of time. On the other hand, in the non-isothermal method, the sample is heated at a fixed rate and then the change in enthalpy is recorded as a function of temperature. Thermal analysis techniques such as differential thermal analysis (DTA) and differential scanning calorimetry (DSC) are quite popular for kinetic analysis of crystallization processes in amorphous solids (Araujo Idalgo, 2009 Malek, 2000 Prasad Varma, 2005). 

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