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Amorphadiene

The entire biosynthesis pathway of artemisinin has not been elucidated yet. The first committed step is conversion of FPP to amorphadiene via the cyclization catalyzed by ADS [102] followed by further oxidations of amorphadiene to artemisinic acid. Artemisinic acid can be used as a precursor for semi-synthesis of artemisinin and related chemicals [88]. [Pg.276]

Three new antiparasitic sesquiterpene isothiocyanates, 4-isothiocyanato-9-amorphene (264), 10-isothiocyanato-4,6-amorphadiene (265) and 10-isothiocyanato-5-amorphen-4-ol (266) were isolated from a Fijian specimen of Axinyssa fenestratus. The compounds were identified by spectral data interpretation [268]. Two isomeric isothiocyanates (267-268) were isolated from Acanthella klethra from the Great Barrier Reef and their structures were determined by X-ray crystallography and spectral data examination [269]. [Pg.662]

O-isothiocyanato-4,6-amorphadiene Axinyssa fenestratus [168] Anthelmintic activity... [Pg.852]

Figure 4 Pathway of artemisinin biosynthesis in Artemisia annua. ADS, amorphadiene synthase CPR, cytochrome P450 reductase. Figure 4 Pathway of artemisinin biosynthesis in Artemisia annua. ADS, amorphadiene synthase CPR, cytochrome P450 reductase.
Fig. 5 Computerized 3D structure of amorpha-4,11-diene. Residues marked with red belong to the conserved metal ion binding amino acid sequence IDxxDD. The 3D model of the amorphadiene synthase (AMDS) courtesy of Wolfgang Brandt, Leibniz Institute of Plant Biochemistry Halle, Germany... Fig. 5 Computerized 3D structure of amorpha-4,11-diene. Residues marked with red belong to the conserved metal ion binding amino acid sequence IDxxDD. The 3D model of the amorphadiene synthase (AMDS) courtesy of Wolfgang Brandt, Leibniz Institute of Plant Biochemistry Halle, Germany...
Figure 2.6 The transfer of a cytochrome P450 enzyme (CYP71 family amorphadiene oxidase)... Figure 2.6 The transfer of a cytochrome P450 enzyme (CYP71 family amorphadiene oxidase)...
Amorphadien-14,2-olide, A-20143 Annulide, A-10093 Caespitenone, C-10009 Chrysorrhedial, in C-10094 Collybial, C-30123... [Pg.536]

Artemisia annua 71AV1 Conversion of amorphadiene to artemisinic acid Sesquiterpene lactones Artemisinin [47]... [Pg.422]

Scheme 98.10 Biosynthesis route to costunolide (82) in Asteraceae compared with artemisinic acid (79) that is spontaneously transformed in artemisinin [44, 48, 49]. ADS amorphadiene synthase, GAS germacrene A synthase, GAO germacrene A oxidase... Scheme 98.10 Biosynthesis route to costunolide (82) in Asteraceae compared with artemisinic acid (79) that is spontaneously transformed in artemisinin [44, 48, 49]. ADS amorphadiene synthase, GAS germacrene A synthase, GAO germacrene A oxidase...
Ammonium sulfate, 3333 Amnesic, 129 Amniotic fluid, 2417 Amorphadiene, 3108 Amorphadiene synthase (ADS), 2832,... [Pg.4164]

See other pages where Amorphadiene is mentioned: [Pg.268]    [Pg.276]    [Pg.276]    [Pg.276]    [Pg.49]    [Pg.247]    [Pg.553]    [Pg.617]    [Pg.21]    [Pg.709]    [Pg.1465]    [Pg.1467]    [Pg.1837]    [Pg.1838]    [Pg.18]    [Pg.19]    [Pg.297]    [Pg.433]    [Pg.20]    [Pg.21]    [Pg.34]    [Pg.54]    [Pg.420]    [Pg.464]    [Pg.537]    [Pg.538]    [Pg.490]    [Pg.520]    [Pg.3082]    [Pg.4162]    [Pg.4624]   
See also in sourсe #XX -- [ Pg.617 ]

See also in sourсe #XX -- [ Pg.4 , Pg.11 , Pg.34 ]



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Amorpha-4,11-diene Amorphadiene

Amorphadiene synthase

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