Amodiaquine hydrochloride tablets

Amodiaquine hydrochloride tablets have been assayed by a method based on the reaction of the drug with 2,3-dichloro-5, 6-dicyano-p-benzoquinone and measurement of the absorbance at 460 nm. The color attains its maximum intensity after five minutes and remains stable for at least one hour. Beer s law is valid in the concentration range 1-4 mg/100 ml, and the recovery is 99.9-102.6% (32). Another colorimetric method for the determination of amodiaquine in tablets depends on its reaction with chloranilic acid in aqueous solution and measurement of the absorbance at 522 nm. The absorbance is linear over the concentration range 0.04 -0.20 mg/ml, and the recovery is 99.9-101.3% (33). 

Abou-Ouf et al. [16] described a spectrophotometric method for the determination of primaquine phosphate in pharmaceutical preparation. Two color reactions for the analysis of primaquine phosphate dosage form, which are based on 2,6-dichlor-oquinone chlorimide and l,2-naphthoquinone-4-sulfonate, were described. The reactions depend on the presence of active centers in the primaquine molecule. These are the hydrogen atoms at position 5 of the quinoline nucleus and the primary amino group of the side chain. The method was applied to tablets of primaquine phosphate and a combination of primaquine phosphate and amodiaquine hydrochloride. 

Hassan et al [18] used a spectrophotometric method for the simultaneous determination of primaquine with amodiaquine mixtures in dosage forms. Crushed tablets containing primaquine phosphate and amodiaquine hydrochloride were extracted with 0.1 M hydrochloric acid, and the mixture was filtered. A portion of the filtrate was diluted with 0.1 M hydrochloric acid, and the absorbance of this solution was measured at 282 and 342 nm against hydrochloric acid. 

The infrared spectrum of amodiaquine has been determined in KBr disc (4). The principal peaks in the infrared spectrum of amodiaquine hydrochloride (KBr disc) are reported at 1565, 815, 1535, 1255, 869, 847 cm (7). Attenuated total reflectance infrared spectrum is used to detect amodiaquine hydrochloride in the solid state as a layer of crystals on adhesive tape. The method has been applied to the identification of the drug in tablet formulations. Common excipients such as starch, and... 

A method for the determination of amodiaquine hydrochloride in tablets by titration with N-bromosucdnimide has been developed (23). The sample is dissolved in water, treated with an acetic acid solution of the reagent and mixed vnth potassium iodide. The iodine released is titrated with sodium thiosulphate solution. The relative standard deviation for the titration is 2.12% and the recovery is 99.4 -101.0%. 

The USP assay (10) of amodiaquine hydrochloride in pure form and in tablets involves ultraviolet spectrophotometric determination. A quantity of the drug equivalent to about 300 mg is dissolved in dilute hydrochloric acid (1 100) to obtain a concentration of about IS The absorbance of this solution, along with a solution of undried USP Amodiaquine Hydrochloride RS in the same medium having a known concentration of about IS Ag/nil, is determined at 342 run using dilute hydrochloric add (1 100) as the blank. The quantity, in mg, of C20H22CIN3O, 2HQ in the portion of amodiaquine hydrochloride taken is calculated the formula 20c (Au/As), in which C is the concentration, in /Amodiaquine Hydrochloride RS in the standard solution and Au and As are the absorbances of the solution of amodiaquine hydrochloride and the standard solution respectively. The same method is applied to the assay of amodiaquine hydrochloride in tablets after extraction of the base into chloroform and then re-extraction with dilute hydrochloric acid (1 100). 

A simple, sensitive, and selective method for the determination of amodiaquine hydrochloride in tablets has been developed. It is based on a color reaction with chloramine-T in the pH range 7.4- 8.0. The chromogen is extracted with chloroform and the absorbance is measured at 442 nm. Beer s law is obeyed in the concentration range 1-200 n%/. The coefficient of variation has been found to be 0.64% and the recovery ranges between 100.3 and 102.5%. Chloroquine phosphate or primaquine phosphate do not interfere with the method (29). 

Amodiaquine hydrochloride has been determined in tablets by dissolving it in water and treating with an acetic add solution of N-bromosucdnimide. An orange-yellow color is produced, whose absorbance is measured at 450 nm. Beer s law is obeyed in the concentration range 15-160/relative standard deviation for the method is 1.44%, and the recovery is 99.7-100.9% (23). 

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