Amodiaquine dosage forms

Abou-Ouf et al. [16] described a spectrophotometric method for the determination of primaquine phosphate in pharmaceutical preparation. Two color reactions for the analysis of primaquine phosphate dosage form, which are based on 2,6-dichlor-oquinone chlorimide and l,2-naphthoquinone-4-sulfonate, were described. The reactions depend on the presence of active centers in the primaquine molecule. These are the hydrogen atoms at position 5 of the quinoline nucleus and the primary amino group of the side chain. The method was applied to tablets of primaquine phosphate and a combination of primaquine phosphate and amodiaquine hydrochloride. 

Hassan et al [18] used a spectrophotometric method for the simultaneous determination of primaquine with amodiaquine mixtures in dosage forms. Crushed tablets containing primaquine phosphate and amodiaquine hydrochloride were extracted with 0.1 M hydrochloric acid, and the mixture was filtered. A portion of the filtrate was diluted with 0.1 M hydrochloric acid, and the absorbance of this solution was measured at 282 and 342 nm against hydrochloric acid. 

The BP method (4) for the assay of amodiaquine hydrochloride as pure drug and in dosage forms is based on nonaqueous titration. A 0.2 g quantity of amodiaquine hydrochloride is dissolved in a suitable volume of anhydrous glacial acetic acid, 7 ml of mercury (11) acetate solution is added and the solution titrated with 0.1 M perchloric acid to a green end point using 1-naphtholbenzoin solution as indicator. In dosage forms, a... 

Amodiaquine can be determined in bulk and in dosage forms by a titrimetric method based on reaction with l,3-dibromo-5,5-dimethylhydantoin or N-bromosuccinimide as the titrant. The mixture is later treated with potassium iodide solution and the liberated iodine titrated with sodium thiosulphate solution. The recovery is about 100% (22). 

Hassan et cd. (27) have developed a method for the simultaneous determination of amodiaquine - primaquine mixtures in dosage forms. The drugs are extracted with 0.1 N hydrochloric acid and absorbance of the mixture is measured at 342 and 282 nm. The concentration of each compound is calculated by solving two simultaneous equations. Excellent... 

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