Sucralfate Amitriptyline

TCAs SUCRALFATE Possible 1 amitriptyline levels l absorption of amitriptyline Watch for poor response to amitriptyline... 

Clinically important, potentially hazardous interactions with amiodarone, amisulpride, amitriptyline, amoxapine, arsenic, bepridil, bretylium, calcium, chlorpromazine, clomipramine, desipramine, disopyramide, doxepin, erythromycin, fluphenazine, imipramine, iron salts, magnesium, mesoridazine, nortriptyline, pentamidine, perphenazine, phenothiazines, pimozide, procainamide, prochlorperazine, promazine, promethazine, protriptyline, quinidine, sotalol, sucralfate, thioridazine, tricyclic antidepressants, trifluoperazine, trimipramine, zinc salts... 

Sucralfate causes a marked reduction in the absorption of amitriptyline. 

When 6 healthy subjects took a single 75-mg dose of amitriptyline with a single 1-g dose of sucralfate, the AUC of the amitriptyline was reduced by 50%. Concurrent use should be monitored to confirm that the therapeutic effects of the antidepressant are not lost. An increase in the dosage may be needed. There seems to be nothing documented about other tricyclics. 

---