Amisulpride metabolism

As amisulpride has no hepatic metabolism, low protein binding, and is directly excreted in urine, there is little reason to suspect pharmacokinetic ethnic differences. Of course body mass and pharmacodynamic differences might occur, but to date have received little investigative attention. 

FLECAINIDE ANTIPSYCHOTICS -PHENOTHIAZINES, AMISULPRIDE, PIMOZIDE, SERTINDOLE Risk of arrhythmias Additive effect. Also, haloperidol and thioridazine inhibit CYP2D6-mediated metabolism of flecainide Avoid co-administration... 

Since amisulpride is only weakly metabolized, few drug interactions that could raise amisulpride plasma levels are expected... 

Aripiprazole for 8 weeks has been used in 24 patients with hyperprolactinemia induced by risperidone, amisulpride, or sulpiride [132 ]. Prolactin concentrations fell from 77 to 18 ng/ml in those taking risperidone, from 145 to 128 in those taking amisulpride, and from 71 to 43 ng/ml in those taking sulpiride. Aripiprazole had no significant effect on metabolic measures or scales of movement adverse reactions. Nevertheless, it should be remembered that antipsychotic drug combinations are not approved for any indication. 

---