Orlistat Amiodarone

Drugs that may affect cyclosporine include allopurinol, amiodarone, androgens (eg, danazol, methyltestosterone), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), azole antifungals (eg, fluconazole, ketoconazole), beta-blockers, bosentan, bromocriptine, calcium channel blockers, colchicine, oral contraceptives, corticosteroids, fluoroquinolones (eg, ciprofloxacin), foscarnet, HMG-CoA reductase inhibitors, imipenem-cilastatin, macrolide antibiotics, methotrexate, metoclopramide, nafcillin, nefazodone, orlistat, potassium-sparing diuretics, probucol, rifamycins (rifampin, rifabutin), serotonin reuptake inhibitors (SSRIs eg, fluoxetine, sertraline),... 

AMIODARONE ANTIOBESITY DRUGS -ORLISTAT Possible 1 amiodarone levels l absorption of amiodarone Watch for poor response to amiodarone... 

Orlistat modestly reduces the absorption of amiodarone, but this is unlikely to be clinically important. 

A randomised placebo-controlled study in 16 healthy subjects found that orlistat 120 mg three times daily reduced the AUC and peak serum level of a single 1,2-g dose of amiodarone by 23% and 27%, respectively. Levels of its active metabolite, desethylamiodarone, were similarly r ueed. The half-life and time to maximum serum level were not significantly altered. It was suggested that orlistat, which inhibits dietary fat absorption, may also reduce the absorption of amiodarone, which is a lipophilic drug. ... 

Zhi J, Moore R, Kanitra L, Mulligan TE. Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers. J Clin Pharmacol (2003) 43, 428-35. 

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