Amiodarone liver injury

It has been suggested that liver injury due to amiodarone is either due to a direct biochemical action or perhaps metabolic idiosyncrasy. Because there have been cases in which oral administration has not led to a recurrence, it has also been suggested that the vehicle in which amiodarone is usually dissolved, polysorbate (Tween) 80, is responsible rather than the amiodarone itself (SEDA-18, 202). 

Waldhauser KM, Torok M, Ha HR, Thomet U, Konrad D, Brecht K, Follath F, Krahenbuhl S (2006) Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives. J Pharmacol Exp Ther 319(3) 1413-1423 Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ (2006) Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 281(22) 15258-15267 Watkins PB (2005) Idiosyncratic liver injury challenges and approaches. Toxicol Pathol 33 (l) l-5... 

Llanos L, Moreu R, Peiro AM, Pascual S, Frances R, Such J, Horga JF, Perez-Mateo M, Zapater P. Causality assessment of liver injury after chronic oral amiodarone intake. Pharmacoepidemiol Drug Saf 2009 18(4) 291-300. 

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